PUBLICATIONS
Journal Articles and Recent Abstracts
Serras F, Kuhtreiber WM, Krul MR and van den Biggelaar JAM (1985) Cell communication compartments in molluscan embryos. Cell Biol Int Rep 9: 731-736
Kuhtreiber WM, van der Bent, J, Dorresteijn AWC, de Graaf A, van den Biggelaar JAM and van Dongen CAM (1986) The presence of an extracellular matrix between cells involved in the determination of the mesoderm bands in embryos of Patella vulgata (Mollusca, Gastropoda). Wilhelm Roux’s Arch Dev Biol 195: 265-275
van den Biggelaar JAM, Kuhtreiber WM, Serras F, Dorresteijn AWC, Beekhuizen H and Schaap D (1986) Analysis of cell communication mechanisms involved in the induction of the stem cell of the mesodermal bands in embryos of Patella vulgata (Mollusca), Acta Histochem suppl 32: 29-33
Kuhtreiber WM (1987) Character and morphogenetic significance of cell communication in the determination of the mesodermal cell line in molluscs. Ph.D. Thesis, University of Utrecht, The Netherlands.
Kuhtreiber WM and Serras F (1987) Direct microinjection of substances in penetration-sensitive embryos. Differentiation 34: 156-159
Kuhtreiber WM, Serras F and van den Biggelaar JAM (1987) Spreading of microinjected horseradish peroxidase to non-descendant cells in embryos of Patella (Mollusca, Gastropoda). Development 100: 713-722
Kuhtreiber WM, van Til EH and van Dongen CAM (1988) Monensin interferes with the determination of the mesodermal cell line in embryos of Patella vulgata. Wilhelm Roux’s Arch Dev Biol 197: 10-18
Kuhtreiber WM and van Dongen CAM (1989) Microinjection of lectins, hyaluronidase and hyaluronate fragments interferes with cleavage delay and mesoderm induction in embryos of Patella vulgata. Dev. Biol. 132: 436-441
Kuhtreiber WM and Jaffe LF (1990) Detection of extracellular calcium gradients with a calcium specific vibrating electrode. J. Cell Biology 110: 1565-1573.
Gillot I, Chrystal J, Jaffe LF and Kuhtreiber W.M. (1990) Where does the calcium lost by fertilizing Arbacia eggs go to? Biol. Bull. 179: 224
Kochian LV, Shaff JE, Kuhtreiber WM, Jaffe LF and Lucas WJ (1992) Use of an extracellular, ion-selective, vibrating microelectrode system for the quantification of H+, K+, and Ca2+ fluxes in maize roots and maize suspension cells. Planta 188: 601-610
Holz GH, Kuhtreiber WM and Habener JF (1992) Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37). Trans Assoc Am Physicians 105: 260 - 267
Kuhtreiber WM, Gillot I, Sardet C and Jaffe LF (1993) Net calcium and acid release at fertilization in eggs of sea urchins and ascidians. Cell Calcium 14: 73-86
Holz GH, Kuhtreiber WM and Habener J (1993) Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 361: 362 - 365
Kuhtreiber WM, Lanza RP, Beyer AM, Kirkland KS, Solomon BA, Muller TE and Chick WL (1993) Relationship between insulin secretion and oxygen tension in hybrid diffusion chambers. ASAIO J 39: M247-251
Kuhtreiber WM, Lanza RP and Chick WL (1994) Secretory function of biohybrid pancreas devices containing isolated porcine islets. ASAIO Journal, 40: M789-792
Kuhtreiber WM, Lanza RP and Chick WL (1994) Bovine islet isolation. In: “Pancreatic Islet Transplantation Series. Volume I: Procurement of Pancreatic Islets”, edited by R.P. Lanza and W.L. Chick (R.G.Landes Company/Medical Intelligence Unit: Austin,TX, 1994 [distributed by CRC Press]). pp.71-80
Lanza RP, Beyer A, Kuhtreiber WM and Chick, WL (1994) Humoral responses to encapsulated islets. Transplantation Proceedings 26: 3346 - 334
Lanza RP, Beyer A, Kuhtreiber WM and Chick WL (1994) Host sensitization by antigens from the biohybrid artificial pancreas. ASAIO J 23: 13Lanza RP, Beyer A,
Kuhtreiber WM and Chick, W.L (1994) Xenogeneic humoral responses to encapsulated islets. Hormone and Metabolic Research, 26: 70
Lanza, RP, Kuhtreiber WM, and Chick WL (1994) Islet transplantation using immunoisolation. Artifical Cells, Blood Substitutes, and Immobilization Biotechnology 22: A26
Lanza, RP, Kuhtreiber WM and Chick WL (1994) Biohybrid devices: Future considerations. Introduction and historical background. In: “Pancreatic Islet Transplantation Series. Volume III: Immunoisolation of Pancreatic Islets”, edited by R.P. Lanza and W.L. Chick (R.G. Landes Company/Medical Intelligence Unit: Austin, TX, 1994 [distributed by CRC Press]). pp.175-180.
Lanza RP, Kuhtreiber WM, Ecker DM, Staruk JE and Chick WL (1995). Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginate microspheres. Transplantation 59:1377-1384
Lanza RP, Kuhtreiber WM, Ecker DM, Marsh JP, Staruk JE and Chick WL (1995) A simple method for transplanting discordant islets into rats using alginate gel spheres. Transplantation, 59: 1485 - 1487
Lanza RP, Kuhtreiber WM, and Chick WL (1995) Encapsulation technologies. Tissue Engineering 1: 181-196
Lanza RP, Kuhtreiber WM, Ecker DM, Marsh JP, Staruk, JE and Chick WL (1995) Successful bovine islet xenografts in rodents and dogs using injectable microreactors. Transplantation Proceedings 27: 3211
Lanza RP, Ecker DM, Kuhtreiber WM, Staruk JE, Marsh JP and Chick WL (1995) A simple and inexpensive method for transplanting discordant xenogeneic islets into rats using alginate gel spheres. Transplantation Proceedings 27: 3322
Lanza RP, Kuhtreiber WM, Ecker DM, Staruk JE and Chick WL (1995) Transplantation of porcine and bovine islets into mice without immunosuppression using uncoated alginate microspheres. Transplantation Proceedings 27: 3321
Lanza, RP, Kuhtreiber WM, Ecker DM, Marsh JP, Staruk JE, Carr S and Chick WL (1996) Xenotransplantation of bovine islets into rodents and dogs without immunosuppression using injectable microreactors. Transplantation Proceedings 28: 830
Lanza, RP, Kuhtreiber WM, Ecker DM, Marsh JP and Chick WL (1996) Preclinical trials using porcine and bovine islets immobilized inside biodegradable microreactors. Diabetes 45: 257A
Lanza RP, Kuhtreiber WM, Ecker DM, Marsh JP, Ringeling J, Staruk JE, and Chick WL (1996) Successful transplantation of encapsulated islets into diabetic rats, rabbits, and NOD mice without immunosuppression. Cell Transplantation 5(5S-2):52
Lanza, RP, Ecker DM, Marsh JP, Kuhtreiber WM, Staruk JE and Chick WL (1996) A simple method of xenotransplanting cells and tissues using uncoated alginate spheres. Transplantation Proceedings 28: 830
Lanza RP, Ecker DM, Kuhtreiber WM, Marsh JP, Ringeling J, and Chick WL (1999) Transplantation of islets using microencapsulation: studies in diabetic rodents and dogs. J Molecular Medicine 77: 206 - 210
Lanza RP and Kuhtreiber WM (1999) Xenotransplantation and Cell Therapy: Progress and Controversy. Molecular Medicine Today 5: 105-106
Lanza RP, Jackson R, Sullivan A, RingelingJ, McGrath C, Staruk J, Kuhtreiber WM and Chick WL (1999) Xenotransplantation of cells and tissues using biodegradable microcapsules. Transplantation 67: 1105-1111
Kuhtreiber WM, Lanza RP and Chick WL (1999) Artificial Pancreas. In: “Encapsulated Cell Technology and Therapeutics” (Kuhtreiber, W.M., Lanza, R.P., and Chick, W.L., Editors) Birkhauser Boston, pp. 217-228
Zimmermann U, Hasse C, Rothmund M and Kuhtreiber WM (1999) Biocompatible encapsulation Materials: Fundamentals and Application. In: “Encapsulated Cell Technology and Therapeutics” (Kuhtreiber WM, Lanza RP and Chick WL, Editors) Birkhauser Boston, pp. 40 - 52
Kuhtreiber WM (1999) Crossing the Species Barrier. Investigational Drugs Weekly Highlights 51: 32-35
Kuhtreiber WM, Hayahsi T, Dale EA, Faustman DL (2003) Central role of defective apoptosis in autoimmunity. J Molec Endocrinol 31: 373-399
Kodama S, Kuhtreiber WM, Fujimura S, Dale EA and Faustman DL (2003) Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 302: 1223-1227
Finn AV, Clermont A, Kolodgie F, Giese N, Kuhtreiber WM, Dale EA, Virmani R, Gold H (2003) A Novel Animal Model of Arterial Stenting in Type II Diabetes Mellitus: Effect of PDGF Inhibition on Neointimal Formation. American Heart Association’s Scientific Sessions. November 9-12, 2003; Orlando, FL
Kuhtreiber WM, Kodama S, Burger DE, Dale EA and Faustman DL (2005). Methods to characterize lymphoid apoptosis in a murine model of autoreactivity. J Immunol Methods 30: 137-150
Ho LT, Zebadua E, Kao P, Urrutia T, Orr C, Ferreri K, Kandeel F and Kuhtreiber WM (2008) Secretion of injury factors by human islets after isolation and hypoxia. 8th Annual Rachmiel Levine Symposium, Newport Beach, CA
Wang T, Adcock J, Kuhtreiber W, Qiang D, Salleng KJ, Trenary I, Williams P (2008). Successful allotransplantation of encapsulated islets in pancreatectomized canines for diabetic management without the use use of immunosuppression. Transplantation 85: 331-337.
Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL (2008) Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proc Natl Acad Sci USA 105: 13644-13649
Kuhtreiber WM, Ho LT, Kamireddy A, Yacoub JAW, Scharp DW (2009) Use of Roche cGMP Liberase MTF C/T in islet isolation from human pancreas with extended cold ischemia time (CIT). 9th Annual Rachmiel Levine Diabetes and Obesity Symposium, Anaheim, CA
Kuhtreiber WM, Ho LT, Kamireddy A, Yacoub JAW, Scharp DW (2009) Islet isolation from human pancreas with extended cold ischemia time (CIT). Abstract and Oral Presentation, IPITA-IXA 2009, Venice, Italy
Kuhtreiber WM, Ho LT, Kamireddy A, Yacoub JAW, Scharp DW (2009) Islet cell isolation from human pancreas with extended cold ischemia time (CIT). Roche Cell Isolation Application Note 1: 1-4
Kuhtreiber WM, Ho LT, Kamireddy A, Yacoub JAW, Scharp DW (2010) Islet isolation from human pancreas with extended cold ischemia time. Transplantation Proceedings 42: 2027-2031
Mirbolooki M, Bozorgmanesh H, Foster CE, Kuhtreiber WM, Lakey JRT (2011) Tissue and Cell Isolation. In: Comprehensive Biotechnology, 2nd edition. Moo-Young M, Butler M. (Eds.), Volume 1, Chapter 44, pp 591-598. Elsevier
Burger DE, Wang L, Ban L, Okubo Y, Kuhtreiber WM, Leichliter AK and Faustman DL (2011) Novel automated blood separations validate whole cell biomarkers. PLoS One 6: e22430 PMCID: PMC3142167
Books
Kuhtreiber WM, Lanza RP and Chick WL (Editors): Encapsulated Cell Technology and Therapeutics. Birkhauser Boston, 1999
Kuhtreiber WM (1987) Character and morphogenetic significance of cell communication in the determination of the mesodermal cell line in molluscs. Ph.D. Thesis, University of Utrecht, The Netherlands
Patents
Lanza RP, Kuhtreiber WM and Chick WL (2000) Microcapsules and Composite Microreactors for Immunoisolation of cells. US Patent 6,126,936
Lanza RP, Kuhtreiber WM and Chick WL (2000) Immunoisolation. Australian Patent 721726
Lanza RP, Kuhtreiber WM and Chick WL (1999) methods of use of uncoated gel particles. US Patent 5,912,005
Lanza RP, Kuhtreiber WM and Chick WL (1997) Methods of use of uncoated gel particles. US Patent 5,651,980
Lanza RP, Kuhtreiber WM and Chick WL (1996) Immunoisolation. International Patent PCT - WO96/28029